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MedImmune,  the global biologics unit of AstraZeneca
Granta Park, Cambridge, UK
Toxicology Project Leader (Senior/Principal Toxicologist)
To help us meet the many challenges that MedImmune’s new horizons present, we have an opportunity to join our growing Toxicology team.

More at: http://www.eurotox.com/doc/2011-MedImmune-Tox%20Advert.pdf

 

 

The term dioxin is commonly used to refer to a family of toxic chemicals that all share a similar chemical structure and a common mechanism of toxic action. This family includes eight of the chlorinated dibenzo dioxins (CDDs), ten of the polychlorinated dibenzo furans (PCDFs) and twelve of the polychlorinated biphenyls (PCBs)(EPA). These are all organochlorine compounds. http://toxipedia.org/display/toxipedia/Dioxin;jsessionid=85072953B1028025D524DEDE8E11E2C6

The most notable poisonings with dioxin were:

Zadnjič posodobljeno (Sreda, 23 Marec 2011 12:44)

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Cultivation of tobacco plants has been known since 6000 BC. When Columbus first discovered a new continent in 1492, he was offered tobacco leaves. The plant was brought back to Europe. Within 200 years, tobacco was carried across the world with various explorers of the time.

Increased cancer incidence due to smoking was first described in 1795, when cancer of lower lip was reported in pipe smokers. Since then a number of studies, including epidemiological studies have revealed that smoking is undoubtedly linked to many types of cancer, as well as other types of diseases.

Zadnjič posodobljeno (Sreda, 23 Marec 2011 12:44)

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Zdravstveni inšpektorat Republike Slovenije je 18.2.2011 na svoji spletni strani objavil, da so v okviru postopkov uradnega nadzora vzorčil živila, pakirana v potiskano kartonsko embalažo, z namenom ugotavljanja prisotnosti fotoiniciatorjev 4-metilbenzofenona in benzofenona, ki lahko zaradi svoje hlapnosti prehajajo skozi plastično embalažo v živila. Izkazalo se je, da je živilo  Jaffa Cakes, 150 g, z datumom uporabe 26.02.2011 ob predvideni izpostavljenosti in ob predpostavki, da fotoiniciatorji migrirajo v živilo 100 %, preseglo zakonsko določeno mejo skupne migracije 4-MBP in BP v živilo 0,6 mg/kg živila. Živilo je bilo znotraj kartonske embalaže pakirano v plastično vrečko iz materiala, ki ne predstavlja funkcionalne pregrade. V kolikor funkcionalna pregrada (npr. aluminijasta folija, PET/SiOx) med kartonsko in plastično embalažo ni vgrajena, lahko tako BP kot 4-MBP zaradi hlapljivosti prehajata v živilo.

Kaj je znanega o benzofenonu (BP) in 4-metilbenzofenonu (4-MBP)?

Zadnjič posodobljeno (Sreda, 23 Marec 2011 12:45)

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We are exposed to mercury mostly via the fish we eat. What kind of symptoms are typical for mercury toxicity, how much of fish is recommended to avoid poisoning and what happened in Minamata 50 years ago.

Mercury is a heavy metal that occurs naturally throughout the environment and can also be released into the air through industrial pollution. Unlike other metals, it is a liquid at normal temperatures and is easily transformed into a gas. Mercury falls from the air and can accumulate in streams and oceans and is turned into methylmercury in the water. Methylmercury is produced mainly by microscopic organisms in the water and soil. Metallic mercury is used to produce chlorine gas and caustic soda, and is also used in thermometers, dental fillings, and batteries. Mercury salts are sometimes used in skin lightening creams and as antiseptic creams and ointments. Fish absorb the methylmercury as they feed in these waters and so it builds up in them (bioaccumulation). It builds up more in predatory fish, such as sharks, swordfish, tuna and others.

Zadnjič posodobljeno (Sreda, 23 Marec 2011 12:46)

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