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4. oktobra 2010 se je na Madžarskem zgodila okoljska katastrofa, pri čemer se je razlila ogromna količina rdeče bazične (pH 12) brozge, ki je vsebovala več različnih toksičnih elementov in spojin nad vrnim nivojem. Na voljo je uradno objavljeno poročilo/članek o vsebnosti in toksičnosti rdeče brozge.

The red mud accident of October 4, 2010, in Ajka (Hungary) contaminated a vast area with caustic, saline red mud (pH 12) that contains several toxic trace metals above soil limits. Red mud was characterized and its toxicity for plants was measured to evaluate the soil contamination risks.

The Red Mud Accident in Ajka (Hungary): Plant Toxicity and Trace Metal Bioavailability in Red Mud Contaminated Soil

Stefan Ruyters , Jelle Mertens, Elvira Vassilieva, Boris Dehandschutter, Andre Poffijn, and Erik Smolders

Environ. Sci. Technol., Article ASAP
DOI: 10.1021/es104000m
Publication Date (Web): January 4, 2011
Copyright © 2010 American Chemical Society



ICH Guidelines: Inception, Revision, and Implications for Drug Development

Tao Wang*,1, David Jacobson-Kram, Anne M. Pilaro, Daniel Lapadula, Abigail Jacobs, Paul Brown,
John Lipscomb§ and William David McGuinn

Since the inception of the International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) in 1990, six-party Expert Working Groups (EWG) have developed and revised numerous guidelines on preclinical safety evaluation...

Link submitted by Chiara Frazzoli
31 May–3 June 2011, University of Buea, Cameroon

The 5th SETAC Africa meeting will be conducted in Buea, Cameroon by SETAC Africa in collaboration with the Cameroon Society for Toxicological Sciences. This four-day conference aims to bring together stakeholders involved in research, production, utilisation, release, management or regulation of toxic chemicals to brainstorm and seek solutions to Africa's human and environmental challenges.

In an effort to be more inclusive and encourage a wider participation of African scientists in this multidisciplinary approach to solving Africa’s human and environmental problems, both English and French will be the official languages of this meeting.


Zadnjič posodobljeno (Petek, 31 December 2010 12:10)


The European Chemicals Agency (ECHA) located in Helsinki

Zadnjič posodobljeno (Petek, 24 December 2010 11:14)

Free access until the end of Dec

Personal care products and endocrine disruption: A critical review of the literature

Critical Reviews in Toxicology, 2010; 40(S3): 1–30

Review article

This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High doses of phthalates in utero can produce “phthalate syndrome,” demasculinizing effects in male rat offspring due to impaired testosterone production by fetal testes. However, evidence linking phthalate exposure to similar effects in humans appears inconclusive. Furthermore, phthalate exposure derived from personal care products is within safe limits and its principal bioavailable phthalate, diethyl phthalate (DEP), does not produce “phthalate syndrome.” Parabens exhibit very weak estrogen activity in vitro and in vivo, but evidence of paraben-induced developmental and reproductive toxicity in vivo lacks consistency and physiological coherence. Evidence attempting to link paraben exposure with human breast cancer is nonexistent. Select UV filters at high doses produce estrogenic, antithyroid, and other effects in rats in vivo. Again, no evidence links UV filter exposure to endocrine disruptive effects in humans. Some polycyclic musks weakly bind to estrogen, androgen, or progestin receptors and exhibit primarily antagonistic activity in vitro, which for the most part, has yet to be confirmed in vivo in mammals. The antimicrobials triclocarban and triclosan evoke weak responses mediated by aryl hydrocarbon, estrogen, and androgen receptors in vitro, which require confirmation in vivo. Preliminary observations suggest a novel interaction between triclocarban and testosterone. In conclusion, although select constituents exhibit interactions with the endocrine system in the laboratory, the evidence linking personal care products to endocrine disruptive effects in humans is for the most part lacking.

Zadnjič posodobljeno (Torek, 21 December 2010 11:23)