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Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk assessment of chemical substances.

It illustrates each step in the process: hazard identification, a dose response assessment, and exposure assessment. The book also summarizes the basic concepts of interaction of chemicals in mixtures and discusses various approaches to testing such mixtures.


- Addresses standards from all international regulatory agencies

- Presents the steps in risk assessment, including hazard identification, exposure assessment, and risk characterization

- Covers the assessment of multiple chemical exposures or chemical mixtures

- Contains data from both human and animal studies Explains the linearized multi-stage mathematical model widely used by the US EPA for characterizing

Publisher: Informa Healthcare

For more information please click on:

Title Index:

- Introduction.

- Data for Hazard Identification and Characterisation.

- Hazard Assessment.

- Exposure Assessment.

- Risk Characterisation.

- Combination Effects.


Hard Copy : EUR 109

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Zadnjič posodobljeno (Sreda, 15 December 2010 18:57)


The comprehensive report itemizes a number of pathways through which the chemicals in tobacco smoke damage the human body and lead to disease and death.

There are more than 7,000 chemicals in tobacco smoke, which the HHS describes as a "deadly" mixture containing hundreds of toxic substances, and at least 70 known to cause cancer.

Published online 6 December 2010 | Nature | doi:10.1038/468742a

Basel Declaration defends animal research

Animal activists last summer set fire to the alpine holiday home of Daniel Vasella, then chief executive of pharmaceutical giant Novartis of Basel, Switzerland, in one of relatively few violent attacks on scientists working with animals in German-speaking countries.

But in the past few years these scientists have been feeling the pressure in other ways — from animal activists who have attempted to publicly shame them or have sent threatening e-mails, and from legislation that increasingly restricts the use of animals in basic research.

Now, in a bid to reverse that trend, more than 50 top scientists working in Germany and Switzerland have launched an education offensive. Meeting in Basel on 29 November, they drafted and signed a declaration pledging to be more open about their research, and to engage in more public dialogue.

"The public tends to have false perceptions about animal research, such as thinking they can always be replaced by alternative methods like cell culture," says Stefan Treue, director of the German Primate Center in Göttingen. Treue co-chaired the Basel meeting, called 'Research at a Crossroads', with molecular biologist Michael Hengartner, dean of science at the University of Zurich, Switzerland. Outreach activities, such as inviting the public into universities to talk to scientists about animal research, "will be helpful to both sides".