The value of acute toxicity testing of pharmaceuticals for estimation of human response

Highlights

Acute oral LD50 of rats have poor correlation with the METD, and cannot be used as a classification criteria. ► Substances with very low therapeutic doses are not identified with the use of oral LD50. ► We propose that the acute toxicity based on rat LD50 dose is not used as a basis for classification of pharmaceuticals.

http://www.sciencedirect.com/science/article/pii/S0273230012000165?v=s5

http://dx.doi.org/10.1016/j.yrtph.2012.01.005