The environment not only alters our genes, but also our gene expression. Alteration of the genes are well documented and can be determined with several validated in vitro and in vivo methods, however aleterations of gene expression is a new and complex field, termed epigenetics.

Epigenetics is the study of heritable changes in gene expression or phenotype occurring
without changes in DNA sequence.

This review focuses on the evidence that the prenatal/fetal period is highly susceptible to
epigenomic dysregulation with implications for health, both lifelong and transgenerationally. There are examples of developmental exposure to various environmental pollutants shown to induce epigenetic changes and neurodevelopmental deficits and diseases.

Prenatal Environmental Exposures, Epigenetics, and Disease

Frederica Perera and Julie Herbstman

Copyright © 2011 Published by Elsevier Inc.


The Stockholm Convention on Persistent Organic Pollutants, which was adopted May 23, 2001 and entered into force on May 17, 2004, is a global treaty whose purpose is to safeguard human health and the environment from highly harmful chemicals that persist in the environment and affect the well-being of humans as well as wildlife.;jsessionid=60A317FC8858FB57D90A483779D2680B



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